Ever since Ozempic became the biggest weight loss craze to hit the nation, there has been no escaping it. So many people are taking it that it caused a shortage of the drug, and using Ozempic (and similar drugs like Wegovy and Mounjaro) has become ubiquitous that it's even being advertised on New York City subways—albeit to mixed responses. As common as it may seem already, since Ozempic is still relatively new in the public discourse, there is one question on everyone's mind. As Andy Cohen posited on Twitter: "Everyone is suddenly showing up 25 pounds lighter. What happens when they stop taking #ozempic?????"
GLP-1 agonists, the family of drugs that Ozempic, Wegovy, and Mounjaro belong to and which contain the active ingredient semaglutide, work on the central nervous system to upregulate the hormone that signals your brain that you are full. They also work to slow down your gastrointestinal tract, helping you feel full for longer. It's not that these drugs are actually working on the fat itself—they're stimulating your brain and body to want less food, leading to weight loss. Essentially they help make dieting easier.
"What happens when you stop the medication is that you're no longer acting on those pathways," says Fatima Cody Stanford, MD, an obesity medicine physician scientist and associate professor of medicine at Harvard Medical School and Massachusetts General Hospital. "Similarly, if you commit to a robust exercise plan for a while and then you stop, it's no longer going to work for you."
Ever since Ozempic became the biggest weight loss craze to hit the nation, there has been no escaping it. So many people are taking it that it caused a shortage of the drug, and using Ozempic (and similar drugs like Wegovy and Mounjaro) has become ubiquitous that it's even being advertised on New York City subways—albeit to mixed responses. As common as it may seem already, since Ozempic is still relatively new in the public discourse, there is one question on everyone's mind. As Andy Cohen posited on Twitter: "Everyone is suddenly showing up 25 pounds lighter. What happens when they stop taking #ozempic?????"
GLP-1 agonists, the family of drugs that Ozempic, Wegovy, and Mounjaro belong to and which contain the active ingredient semaglutide, work on the central nervous system to upregulate the hormone that signals your brain that you are full. They also work to slow down your gastrointestinal tract, helping you feel full for longer. It's not that these drugs are actually working on the fat itself—they're stimulating your brain and body to want less food, leading to weight loss. Essentially they help make dieting easier.
"What happens when you stop the medication is that you're no longer acting on those pathways," says Fatima Cody Stanford, MD, an obesity medicine physician scientist and associate professor of medicine at Harvard Medical School and Massachusetts General Hospital. "Similarly, if you commit to a robust exercise plan for a while and then you stop, it's no longer going to work for you." |
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