Uncovering Alzheimer’s Disease Pathology with Single Cell Sequencing

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Understanding Microglial Response in Alzheimer's Disease

A diverse population of microglial cells resides in the brain. Similar to immune cells, microglial cells respond to minute changes in their environment. Sometimes this response is beneficial and other times detrimental. Scientists are working to tease apart the dynamic role of microglial response in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease.

In this episode, Tiffany Garbutt from The Scientist's Creative Services team spoke with Samuel Marsh, a postdoctoral research fellow in the laboratory of Beth Stevens at Boston's Children's Hospital and Harvard Medical School, about how he uses single cell technology and spatial transcriptomics to better understand the role of microglia in Alzheimer's disease pathogenesis.

The Scientist Speaks is a podcast produced by The Scientist's Creative Services team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research. This month's episode is sponsored by 10x Genomics.

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