Functional genetic screens are a powerful tool for establishing links between genotypes and phenotypes. They are particularly relevant for identifying potential genetic factors underpinning disease onset or progression. Over the past decade, technological and methodological breakthroughs have advanced screening processes. In particular, the emergence of CRISPR allows researchers to modulate gene expression in a controlled, robust, and highly specific manner.
Download this ebook from Synthego to learn how researchers use CRISPR-mediated loss-of-function screens to identify and validate gene targets for drug discovery.
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OLIVER HOLT: The horror of relegation haunts Chris Ramsey just as it haunts every other manager who is scrambling and scrapping to try to escape it. But for Ramsey there is a wider fear, too. from Articles | Mail Online http://www.dailymail.co.uk/sport/football/article-3075023/Chris-Ramsey-heat-relegation-QPR-mean-black-managers-Premier-League.html?ITO=1490&ns_mchannel=rss&ns_campaign=1490
Uproxx Once upon a time, on a flight from Los Angeles to Oklahoma, a man behind me described the concept of a “ Make Your Own Burger ” restaurant to his seat partner. “First, you pick a bun!” he said in loud bellow, meant for the nearly deaf or perhaps to scare away any bears that might be on the airplane. I did not see him, but I imagine he was also lifting his arms up to look big and imposing. Airplane bears are easily frightened if you look large and are loud. “You can pick a regular bun,” he continued, shouting. “Or a sesame bun. They’ve got those pretzel buns, honey wheat. Or a Hawaiian bun. Or…” he said as if he were about to reveal the location of the Holy Grail, “you could do no bun at all! Make it a salad.” While I appreciated the man’s enthusiasm as he described (topping by topping) every goddamn choice one could possibly find at a “Make Your Own Burger ” establishment, it was 5:30am. I had been up since 3am. And I thought I was going to get to nap, but instead, I spen
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